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Thus, we have demonstrated that cellular lipidosis is the principal event in the genesis of atherosclerotic lesion. We developed an approach to prevent lipid accumulation in arterial cells. This led to regression of atherosclerosis in patients. So, our basic science was successfully translated into clinical practice. As a result of this translation novel approach to antiatherosclerotic therapy was developed. On the basis of our knowledge we developed a drug possessing direct antiatherosclerotic activity. Our clinical trial confirmed the efficacy of both new approach and new drug.