Thus, we have shown that cellular lipidosis is the principal event in genesis of atherosclerotic lesion. We developed an approach to prevent lipid accumulation in arterial cells. This led to regression of atherosclerosis in patients. So, our basic findings were successfully translated into clinical practice. As a result of this translation novel approach to antiatherosclerotic therapy was developed. On the basis of our knowledge we developed drugs possessing direct antiatherosclerotic activity. Our clinical trials confirmed the efficacy both new approach and new drugs.