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Patol Fiziol Eksp Ter. 2011 Oct-Dec;(4):29-32.


Methods of proteomics were used to show the influence of parathyroid hormone (PTH, fragment 1-34) on osteoblasts as a major component of the hematopoietic stem cell niche. It was found that a number of proteins are changing in response to PTH treatment for 4, 8 and 32 hours. The experimental work-flow has been optimised for the systematic identification of protein level changes upon cellular exposure to different environments.