On this scheme I tried to sum up all potential roles of revealed genes in the ER and the ER stress.

The main protein here is PERK.

 Insig-1 overexpression protected β cells from ER stress-induced apoptosis 

Endogenous ANXA1, functioning as a scaffolding protein, is imperative in membrane organization and trafficking.

(In normal macrophages, low density lipoprotein (LDL) cholesterol particles are loaded from late endosomes to the ER. In the ER, cholesterol is esterified and accumulates to form inert lipid droplets. In atherosclerotic macrophages, ER-mediated cholesterol reesterificationis markedly reduced or failed resulting in heavy intracellular deposits of nonesterifiedcholesterol in foam cell.)