We identified signaling pathways that undergo up-regulation and down-regulation as a result of macrophage interaction with the studied samples. The upper panel shows all the tested samples. The bottom panel is simpler where only signaling pathways that change when interacting with native LDL (control), as well as latex beads and multiple modified LDL isolated from the blood of atherosclerotic patients are presented. Since we are interested in the mechanisms of accumulation of intracellular lipids, we excluded from consideration native LDL that does not cause lipid accumulation. On the other hand, there are signaling pathways that change similarly in both cases of latex beads and modified LDL. Among these signaling pathways, four underwent up-regulation and eight were down-regulated. What could be common between latex beads and modified LDL? This is a stimulation of phagocytosis. Modified LDL forms self-associates that are comparable in size to latex beads and cannot interact with a specific LDL receptor but are taken up by the cell through phagocytosis. As is known, the stimulation of phagocytosis is a trigger for the pro-inflammatory response of the macrophage which is accompanied by the secretion of pro-inflammatory cytokines. Perhaps the identified common signaling pathways for latex and LDL are involved in the pro-inflammatory response of the cell.