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Yuliya V Markina, Alexander M Markin, Tatiana V Kirichenko, Taisiya V Tolstik, Vadim R Cherednichenko, Diana G Kiseleva, Alexander N Orekhov

Front Biosci (Schol Ed) . 2023 Dec 27;15(4):17. doi: 10.31083/j.fbs1504017.


Background: Mitochondrial dysfunction is considered an important mechanism in the pathogenesis of various diseases. Therefore, mitochondria are currently being considered as subjects for targeted therapies, particularly, phototherapy using 5-aminolevulinic acid. This study aimed to investigate the activity of mitochondria in cells with different mutation loads.


Materials and methods: The study was conducted using 11 cybrid lines obtained from the THP-1 cell line (a human monocytic leukemia cell line) and platelets of patients with different mitochondrial mutations.


Results: Our results illustrate that 5-aminolevulinic acid was metabolized equally in all cell lines, however, there was a significant decrease in mitochondrial potential, which differed among lines.


Conclusions: The results of this study can be used to develop a personalized therapeutic approach based on different mitochondrial activities.


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