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Volobueva AS, Melnichenko AA, Grechko AV, Orekhov AN.

Ther Clin Risk Manag. 2018 Feb 9;14:237-245. doi: 10.2147/TCRM.S153895. eCollection 2018.


Mitochondria are the key players in cell metabolism, calcium homeostasis, and reactive oxygen species (ROS) production. Mitochondrial genome alterations are reported to be associated with numerous human disorders affecting nearly all tissues. In this review, we discuss the available information on the involvement of mitochondrial DNA (mtDNA) mutations in cell dysfunction.


ATP; apoptosis; electron transfer chain; mitochondria; mutation; reactive oxygen species


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