Chistiakov DA, Bobryshev YV, Kozarov E, Sobenin IA, Orekhov AN.
Front Microbiol. 2015 Jan 13;5:781. doi: 10.3389/fmicb.2014.00781. eCollection 2014.
The mucosal barriers are very sensitive to pathogenic infection, thereby assuming the capacity of the mucosal immune system to induce protective immunity to harmful antigens and tolerance against harmless substances. This review provides current information about mechanisms of induction of mucosal tolerance and about impact of gut microbiota to mucosal tolerance.
KEYWORDS: harmful antigens; immune system; intestinal microbiota; microflora; tolerance