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Karagodin V.P., Bobryshev Y.V., Chistiakov D.A., Orekhov A.N.

Journal of Basic and Applied Medicine PATHOGENESIS v. 12, №2 2014


The review deals with the dif ferent a pects of de dritic cells (DCs) in atherogenesis. Implement tion of the effector functions of dendritic cells, expressed either in a tivation or su pression of i mune responses, depends on their tis sue microenvironment. The balance b tween inflammatory and anti-inflammatory ef fects of dendritic cells is mediated by regulatory T-cells as well. DC phenotypes are described for mature and precursor cells.
Keywords: dendritic cells, atherosclerosis, inflammation, regulatory T-cells, subsets of DC.

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