Heterogeneity of Tregs and the complexity in the IL-12 cytokine family signaling in driving T-cell immune responses in atherosclerotic vessels.

Chistiakov DA, Bobryshev YV, Orekhov AN.

Mol Immunol. 2015 Feb 3;65(1):133-138. doi: 10.1016/j.molimm.2015.01.013. [Epub ahead of print]

Abstract

The importance of immune inflammation in the development and progression of atherosclerotic lesions is well recognized. Accumulated evidence shows striking features of heterogeneity of regulatory T cells (Tregs) and the importance of the IL-12 cytokine family in regulation of Tregs in atherogenesis. The present review briefly summarized the current knowledge about the impact of the IL-12 cytokine family in regulation of immune processes in atherogenesis.

KEYWORDS: Arteries; Atherosclerosis; Immune reactions; Inflammation; Interleukin 12