Orekhov AN, Safraz'ian NL, Chirkov IuIu, Tertov VV, Sobolev AS
Biull Eksp Biol Med 1978 Feb 85:2 164-7

Abstract

Early alterations in the enzyme activities controlling cyclic adenosine-3',5'-monophosphate (cAMP) metabolism after the irradiation (800 rad) of mice were found in the lymphoid cells of the spleen and thymus. Postradiation disturbances in these activities' ration induced alterations in cAMP steady-state concentrations in the cell. It was also demonstrated that irradiation reduced lymphoid cell ability to accumulate cAMP in response to isoproterenol administration.