Tertov VV, Orekhov AN, Repin VS, Smirnov VN
Biull Eksp Biol Med 1983 May 95:5 92-3
Dibutyrly-cAMP (db-cAMP) reduces the content of cholesterol esters in intimal cells obtained from atherosclerotic areas of human aorta. This effect depends on the nucleotide concentration. Db-cAMP has no effect on the content of cholesterol esters in the cells obtained from unaffected aortic areas. It can be assumed that cAMP derivatives and agents that give rise to the increased cAMP level in the cells may impede the development of the atherosclerotic manifestation such as lipoidosis.