научный сотрудник
Василий Николаевич Сухоруков, магистр биологии
Дата рождения: 09.03.1986
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телефон: +7(915)3933263.
E-mail:
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Работа:
Научный сотрудник лаборатории клеточной и молекулярной патологии сердечно-
сосудистой системы ФГБНУ НИИ Морфологии Человека
Образование:
2007 бакалавр биологии, факультет биологии и почвоведения, Санкт-Петербургский
государственый университет, Санкт-Петербург, Россия
2009 магистр биологии, факультет биологии и почвоведения, Санкт-Петербургский
государственый университет, Санкт-Петербург, Россия
Работа и доп образование:
2011-2013: аспирант, Санкт-Петербургский государственый университет, Санкт-
Петербург, Россия
2013 - 2015: научный сотрудник в лаборатории гриппозных вакцин, НИИ Гриппа, Санкт-
Петербург, Россия
2015 - 2017: стажировка в INSERM Unit 1166 ICAN, Hospital La Pitié, Париж, Франция
2015 – н.в. ФГБНУ НИИ Патологии и Патофизиологии
2019 – н.в. ФГБНУ НИИ Морфологии Человека
2019 – н.в. НМИЦ Кардиологии
Награды:
2018 Young Investigator Award, 11 th APSAVD Congress, Iloilo
2018 Young Investigator Fellowship, 86 th EAS Congress 2018, Lisbon
2018 Travel Grant, XVIII International Symposium on Atherosclerosis (ISA), Toronto
2019 Young Investigator Award, 12 th APSAVD Congress, Taipei
2019 ESC Educational Grant, ESC CONGRESS 2019, Paris
Членство в международных обществах и ассоциациях:
Member, European Atherosclerotic Society
Member, Russian Academy of Natural Sciences
Member, European Society of Cardiology
Другое
Приглашенный редактор в журнале Current Pharmaceutical Design
Список публикаций:
1. Sukhorukov VN, Khotina VA, Bagheri Ekta M, Ivanova EA, Sobenin IA, Orekhov
AN. Endoplasmic Reticulum Stress in Macrophages: The Vicious Circle of Lipid
Accumulation and Pro-Inflammatory Response. Biomedicines. 2020;8(7):E210.
Published 2020 Jul 13. doi:10.3390/biomedicines8070210 MH SCOPUS Q1;
IMPACT FACTOR – 4.717
2. Tatiana V. Kirichenko, Vasily N. Sukhorukov, Alexander M. Markin, Nikita G. Nikiforov,
Ping-Yen Liu, Igor A. Sobenin, Vadim V. Tarasov, Alexander N. Orekhov and Gjumrakch
Aliev. Medicinal Plants as a Potential and Successful Treatment Option in the Context of
Atherosclerosis. Front. Pharmacol., 08 April 2020; doi.org/10.3389/fphar.2020.00403
MH SCOPUS Q1; IMPACT FACTOR – 4.225
3. Poznyak AV, Wu WK, Melnichenko AA, Wetzker R, Sukhorukov V, Markin AM,
Khotina VA, Orekhov AN. Signaling Pathways and Key Genes Involved in
Regulation of foam Cell Formation in Atherosclerosis. Cells. 2020 Mar
1;9(3):E584. doi: 10.3390/cells9030584. PMID: 32121535. MH SCOPUS Q1;
IMPACT FACTOR – 4.366
4. Igor A. Sobenin, Vasily N. Sukhorukov. Current Trends in Vascular Biology and
Atherothrombosis. Current Pharmaceutical Design Volume 26 , Issue 1 , 2020 DOI :
10.2174/138161282601200225102449 MH SCOPUS Q2; IMPACT FACTOR –
2.208
5. Orekhov, A.N.; Nikiforov, N.G.; Sukhorukov, V.N.; Kubekina, M.V.; Sobenin, I.A.; Wu, W.-
K.; Foxx, K.K.; Pintus, S.; Stegmaier, P.; Stelmashenko, D.; Kel, A.; Gratchev, A.N.;
Melnichenko, A.A.; Wetzker, R.; Summerhill, V.I.; Manabe, I.; Oishi, Y. Role of
Phagocytosis in the Pro-Inflammatory Response in LDL-Induced Foam Cell Formation; a
Transcriptome Analysis. Int. J. Mol. Sci. 2020, 21, 817. doi.org/10.3390/ijms21030817
MH SCOPUS Q1; IMPACT FACTOR – 4.556
6. Vasily P. Karagodin, Vasily N. Sukhorukov, Alexander N. Orekhov, Shaw-Fang Yet, Igor A.
Sobenin. «Atherosclerosis prevention: the role of special diets and functional foods. MH
[Frontiers in Bioscience, Elite, 12, 95-101, Jan 1, 2020]. dx.doi.org/10.2741/E859
SCOPUS Q2; IMPACT FACTOR – 1.94
7. Vasily Petrovich Karagodin, Vasily Nikolaevich Sukhorukov, Alexander Nikolaevich
Orekhov, Shaw-Fang Yet, Igor Alexandrovich Sobenin. Prevention of atherosclerosis: the
role of special diets and functional foods. [DOI No:10.2741/S540] [PubMed No:
1][Metrics] [Frontiers in Bioscience, Scholar, 12, 57-69, Jan 1, 2020]. MH SCOPUS
Q2; IMPACT FACTOR – 1.48
8. Sobenin IA, Zhelankin AV, Khasanova ZB, Sinyov VV, Medvedeva LV, Sagaidak MO,
Makeev VJ, Kolmychkova KI, Smirnova AS, Sukhorukov VN, Postnov AY, Grechko
AV,Orekhov AN. Heteroplasmic Variants of Mitochondrial DNA in Atherosclerotic
Lesions of Human Aortic Intima. Biomolecules. 2019 Sep 6;9(9). pii: E455.
doi:10.3390/biom9090455. PubMed PMID: 31500189. Q1 MH SCOPUS Q1; IMPACT
FACTOR – 4.694
9. Sukhorukov VN, Orekhov AN. Genetic and Molecular Approaches to Drug Target
Discovery for Treatment of the most Dangerous Diseases that are Rapidly Increasing
Globally. Part II. Curr Pharm Des. 2019;25(6):625-626. doi:
10.2174/138161282506190516100854. PubMed PMID: 31223075. SCOPUS Q2;
IMPACT FACTOR – 2.208
10. Sukhorukov VN, Orekhov AN. Genetic and Molecular Approaches to Drug Target
Discovery for Treatment of the most Dangerous Diseases that are Rapidly Increasing
Globally. Part I. Curr Pharm Des. 2019;25(3):211-212.
doi:10.2174/138161282503190514123728. PubMed PMID: 31198110. SCOPUS Q2;
IMPACT FACTOR – 2.208
11. Myasoedova VA, Sukhorukov V, Grechko AV, Zhang D, Romanenko E, Orekhov V,
Orekhov AN. Inhibitors of DNA Methylation and Histone Deacetylation as
Epigenetically Active Drugs for Anticancer Therapy. Curr Pharm Des. 2019;25(6):635-
641. doi: 10.2174/1381612825666190405144026. PubMed PMID: 30950345. MH
SCOPUS Q2; IMPACT FACTOR – 2.208
12. Sukhorukov V, Gudelj I, Pučić-Baković M, Zakiev E, Orekhov A, Kontush A, Lauc G.
Glycosylation of human plasma lipoproteins reveals a high level of diversity, which
directly impacts their functional properties. Biochim Biophys Acta Mol Cell Biol Lipids.
2019 May;1864(5):643-653. doi: 10.1016/j.bbalip.2019.01.005. Epub 2019 Jan 12.
PubMed PMID: 30641224. SCOPUS Q1; IMPACT FACTOR – 4.519
13. Glanz V, Myasoedova VA, Sukhorukov V, Grechko A, Zhang D, Romaneneko EB,
Orekhova VA, Orekhov A. Transcriptional characteristics of activated macrophages. Curr
Pharm Des. 2019 Mar 19. doi: 10.2174/1381612825666190319120132. [Epub ahead of
print] PubMed PMID: 30892154. SCOPUS Q2; IMPACT FACTOR – 2.208
14. Orekhov AN, Sukhorukov VN. Current Approaches to Diagnostics and Therapies of
Chronic Diseases: Focus on Molecular and Cell Biology. Curr Pharm Des.
2018;24(24):2757-2759. doi: 10.2174/138161282424181108110309. PubMed PMID:
30426892. SCOPUS Q2; IMPACT FACTOR – 2.208
15. Orekhov AN, Sukhorukov VN. Translation of Basic Research into Clinical Practice:
Focus on Cell-Based Diagnostics and Therapy. Curr Pharm Des. 2018;24(26):3005-3007.
doi: 10.2174/138161282426181114141551. SCOPUS Q2; IMPACT FACTOR –
2.208
16. Karagodin VP, Sukhorukov VN, Myasoedova VA, Grechko AV, Orekhov AN.
Diagnostics and Therapy of Human Diseases - Focus on Sialidases. Curr Pharm Des.
2018;24(24):2870-2875. doi: 10.2174/1381612824666180910125051. PubMed PMID:
30198428. SCOPUS Q2; IMPACT FACTOR – 2.208
17. Orekhov AN, Pushkarsky T, Oishi Y, Nikiforov NG, Zhelankin AV, Dubrovsky L,
Makeev VJ, Foxx K, Jin X, Kruth HS, Sobenin IA, Sukhorukov VN, Zakiev ER, Kontush
A, Le Goff W, Bukrinsky M. HDL activates expression of genes stimulating cholesterol
efflux in human monocyte-derived macrophages. Exp Mol Pathol. 2018 Oct;105(2):202-
207. doi: 10.1016/j.yexmp.2018.08.003. Epub 2018 Aug 16. PubMed PMID: 30118702;
PubMed Central PMCID: PMC6247801. SCOPUS Q2; IMPACT FACTOR – 2.31
18. Sukhorukov VN, Karagodin VP, Zakiev ER, Grechko AV, Orekhov AN. Sialidases:
Therapeutic and Antiatherogenic Potential. Curr Pharm Des. 2017;23(31):4696-4701.
doi: 10.2174/1381612823666170609082324. Review. PubMed PMID: 28911304.
SCOPUS Q2; IMPACT FACTOR – 2.208
19. Zakiev ER, Sukhorukov VN, Ivanova EA, Orekhov AN. Analysis of Apolipoprotein B
Protein of Circulating Multiple-Modified Low-Density Lipoprotein. Int J Angiol. 2017
Mar;26(1):49-52. doi: 10.1055/s-0036-1588062. Epub 2016 Dec 26. PubMed PMID:
28255216; PubMed Central PMCID: PMC5330755. SCOPUS Q3; IMPACT FACTOR
– ?
20. Nikiforov NG, Zakiev ER, Elizova NV, Sukhorukov VN, Orekhov AN. Multiple-
modified Low-Density Lipoprotein as Atherogenic Factor of Patients' Blood:
Development of Therapeutic Approaches to Reduce Blood Atherogenicity. Curr Pharm
Des. 2017;23(6):932-936. doi: 10.2174/1381612823666170124112918. Review. PubMed
PMID: 28120723. SCOPUS Q2; IMPACT FACTOR – 2.208
21. Ryzhkova AI, Karagodin VP, Sukhorukov VN, Sazonova MA, Orekhov AN.
[DESIALATED LOW DENSITY LIPOPROTEINS IN HUMAN BLOOD]. Klin Med
(Mosk). 2017;95(3):216-21. Russian. PubMed PMID: 30303339. SCOPUS Q4
22. Gomez Rosso L, Lhomme M, Meroño T, Dellepiane A, Sorroche P, Hedjazi L, Zakiev E,
Sukhorukov V, Orekhov A, Gasparri J, Chapman MJ, Brites F, Kontush A. Poor
glycemic control in type 2 diabetes enhances functional and compositional alterations of
small, dense HDL3c. Biochim Biophys Acta Mol Cell Biol Lipids. 2017
Feb;1862(2):188-195. doi: 10.1016/j.bbalip.2016.10.014. Epub 2016 Nov 2. PubMed
PMID: 27815221. SCOPUS Q1; IMPACT FACTOR – 4.519
23. Zakiev E, Feng M, Sukhorukov V, Kontush A. HDL-Targeting Therapeutics: Past,
Present and Future. Curr Pharm Des. 2017;23(8):1207-1215. doi:
10.2174/1381612822666161027153140. Review. PubMed PMID: 27799042. SCOPUS
Q2; IMPACT FACTOR – 2.208
24. Alipov VI, Sukhorukov VN, Karagodin VP, Grechko AV, Orekhov AN. Chemical
composition of circulating native and desialylated low density lipoprotein: what is the
difference? Vessel Plus 2017;1:107-15. 10.20517/2574-1209.2017.20
25. Zakiev ER, Sobenin IA, Sukhorukov VN, Myasoedova VA, Ivanova EA, Orekhov AN.
Carbohydrate composition of circulating multiple-modified low-density lipoprotein. Vasc
Health Risk Manag. 2016 Oct 14;12:379-385. eCollection 2016. PubMed PMID:
27789955; PubMed Central PMCID: PMC5072518. SCOPUS Q1; IMPACT FACTOR
– 2.62
26. Sukhorukov VN, Karagodin VP, Orekhov AN. [Atherogenic modification of low-density
lipoproteins]. Biomed Khim. 2016 May;62(4):391-402. doi:
10.18097/PBMC20166204391. Review. Russian. PubMed PMID: 27562992. SCOPUS
Q3
27. Zakiev ER, Sukhorukov VN, Melnichenko AA, Sobenin IA, Ivanova EA, Orekhov AN.
Lipid composition of circulating multiple-modified low density lipoprotein. Lipids Health
Dis. 2016 Aug 24;15(1):134. doi: 10.1186/s12944-016-0308-2. PubMed PMID:
27558696; PubMed Central PMCID: PMC4995786. SCOPUS Q2; IMPACT FACTOR
–
28. Sukhorukov VN, Karagodin VP, Orekhov AN. [Modern methods of diagnosis
dyslipidemia ]. Patol Fiziol Eksp Ter. 2016 Jan-Mar;60(1):65-72. Review. Russian.
PubMed PMID: 29215251. SCOPUS Q4
29. Sukhorukov V.N., Camont L., Lhomme M., Karagodin V.P., Chapman M.J., Kontush A.,
Orekhov A.N. Novel liquid chromatography-mass spectrometrymethod to analyze hdl
lipidome. Patol Fiziol Eksp Ter. 2016 Jul-Sep;60(3):95-100. PubMed PMID: 29244914.
SCOPUS Q4
30. Smirnova AV, Sukhorukov VN, Karagodin VP, Orekhov AN. [Epigenetic factors in
atherogenesis: microRNA]. Biomed Khim. 2016 Mar-Apr;62(2):134-40. doi:
10.18097/PBMC20166202134. Review. Russian. PubMed PMID: 27143369. SCOPUS
Q3
31. Ryzhkova AI, Karagodin VP, Sukhorukov VN, Sazonova MA, Orekhov AN.
[DESIALATED LOW DENSITY LIPOPROTEINS IN HUMAN BLOOD]. Klin Med
(Mosk). 2017;95(3):216-21. Russian. PubMed PMID: 30303339. (Рыжкова А.И.,
Иванова Е.А., Сухоруков В.Н., Карагодин В.П., Сазонова М.А., Орехов А.Н.
Электроотрицательные липопротеиды низкой плотности. Патогенез. 2016. Т. 14. №
3. С. 11-16.)
32. Маркин А.М., Маркина Ю.В., Сухоруков В.Н., Хайлов А.М., Орехов А.Н. Роль
физических нагрузок в развитии атеросклеротических поражений сосудистой
стенки. Клин. эксп. морфология. 2019;8(4):25–31. DOI:10.31088/CEM2019.8.4.25-31
Conferences
1. Vasily Sukhorukov, Nikita Nikiforov, Kira Kolmychkova, Igor Sobenin, Marina Kubekina,
Alexander Orekhov. Role of inflammation-related genes in macrophage cholesterol
accumulation. 25 th Annual Scandinavian Atherosclerosis Conference, Krogerup Hojskole,
Humlebaek, Denmark, April 10-13, 2019; p.104
2. Bakovic MP, Sukhorukov V, Zakiev E, Orekhov A, Lauc G, Kontush A. Sialylation of human
plasma lipoproteins as a key determinant of biological function. 85th EAS Congress, Prague,
Czech Republic, April 23-26, 2017
3. Sukhorukov VN, Orekhov AN, Oishi Y. Transcriptome analysis revealed genes related to
cholesterol efflux. The 11th Asian-Pacific Society of Atherosclerosis and Vascular Disease
Congress, IloIlo, Philippines, February 27 – March 1, 2018, Abstract. Oral Presentation,
ENTRY#21
4. Zakiev E, Ma F, Rached F, Lhomme M, Sukhorukov V, Serrano CV, Santos RD, Chapman
MJ, Orekhov A, Kon-tush A. Unsaturated, low-abundant species of HDL (Lyso)phospholipids
are most affected by ST segment ele-vation myocardial infarction. 86th Congress of the
European Atherosclerosis Society (EAS), Lisbon, Portugal, May 05-08, 2018, poster SAG23.4.
Atherosclerosis 2018, 275:e56-e57. doi: 10.1016/j.atherosclerosis.2018.06.152.
IF(2017/2018)=4.467, SJR(2017)=1.967 (Q1).
5. Sukhorukov V, Zakiev E, Nikiforov N, Oishi Y, Zhelankin A, Sobenin I, Makeev V, Kontush A,
Le Goff W, Foxx K, Kruth H, Jin X, Bukrinsky M, Orekhov A. Transcriptome analysis of human
macrophages reveals genes regulat-ing cellular cholesterol efflux. 86th Congress of the
European Atherosclerosis Society (EAS), Lisbon, Portugal, May 05-08, 2018, poster SAG19.1.
Atherosclerosis 2018, 275:e48. doi: 10.1016/j.atherosclerosis.2018.06.127.
IF(2017/2018)=4.467, SJR(2017)=1.967 (Q1).
6. Orekhov AN, Sukhorukov VN, Oishi Y. Genes Related to Cholesterol Efflux (Transcriptome
Analysis). Abstracts, XVIII International Symposium on Atherosclerosis, Toronto, Canada, June
9 - 12, 2018, 378 [Orekhov AN, Su-khorukov VN, Oishi Y. Genes related to cholesterol efflux
(transcriptome analysis). International Symposium on Atherosclerosis (ISA), Toronto, Canada,
June 09-12, 2018, poster 3.123. Atherosclerosis Suppl 2018, 32:124-125. doi:
10.1016/j.atherosclerosissup.2018.04.382. IF(2016/2017)=2.852. SJR(2017)=0.777 (Q2).]
7. Sukhorukov V, Zakiev E, Oishi Y, Kontush A, Orekhov A. Transcriptome analysis of
monocyte-derived macro-phages revealed genes associated with cellular cholesterol efflux.
European Lipoprotein Club, 41th Annual Meeting, September 10-13, 2018, Tutzing, Germany;
p. 81
8. Orekhov AN, Nikiforov NG, Sukhorukov VN. Transcriptome analysis of macrophages
interacting with lipoprooteins. World Congress of Cardiology & Cardiovascular Health 2018,
December 5-o 8, 2018, Dubai, United Arab Emirates; Global Heart 2018,13(4)411
9. Nikiforov NG, Sukhorukov VN, Kubekina MV, Kolmychkova KI, Oishi Y, Orekhov AN.
Inflammatory genes regulate cholesterol metabolism. World Congress of Cardiology &
Cardiovascular Health 2018, December 5-o 8, 2018, Dubai, United Arab Emirates; Global Heart
2018,13(4)396
10. Vasily Sukhorukov, Maja Pučić Baković, Emile Zakiev, Alexander Orekhov, Anatol Kontush,
Gordan Lauc. Glycome of Human Plasma Lipoproteins: High Diversity and Biological
Implications, Oral Presentation, Congrès NSFA 2017, June 21-23, 2017, Biarritz, France; p.52
Number of publications: 28. H-index 5 (according to Scopus).