Atherosclerosis prevention in postmenopausal women is a striking problem. Hormone replacement therapy was rejected as a tool for atherosclerosis prevention. Phytoestrogens are often regarded as a possible alternative to hormone replacement therapy, but practically nothing is known on their effects on atherosclerosis. We have developes phytoestrogen-rich combination of natural botanicals: garlic powder, extract of grape seeds, green tea leafs and hop cones - all produced a significant antiatherogenic effect.On the basis of this combination plus vitamins-antioxidants the novel dietary supplement karinat was developed.