These results encouraged clinical trials of other drugs based on natural products, including inflaminat, possessing anti-cytokine activity. Atherosclerosis is regarded as a pathological process with elements of local aseptic inflammation, while inflammatory cytokines play a role at every stage of atherosclerosis development. In our study, we investigated the atherosclerosis regression effect of natural drug inflaminat based on calendula, elder and violet. These plants are widely used in herbal medicine as anti-inflammatory agents.