What are the changes at the cellular level during atheroslerosis development? according to conventional classification of atherosclerosis normal arterial wall is "0". Lesion type one is initial lesion which can be revealed only microscopically as accumulation of lipid droplets in arterial intima. Lesion type two is fatty streak - local lipid accumulation. also one lipid-rich lesion is fibrolipid plaque having lipid core and fibrotic cap. This is lesion five-a. Favourable development leads to lision five-c, that is fibrotic plaque with low lipid content and huge fibritic cap.