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Galitsyna EV, Sazonova MA, Shkurat TP, Demakova NA, Melnichenko AA, Sinyov VV, Ryzhkova AI, Mitrofanov KY, Zhelankin AV, Sobenin IA, Orekhov AN.

Curr Pharm Des. 2016 Oct 18. [Epub ahead of print]

Abstract

The present article considers chronic diseases of non-inflammatory genesis, the reasons of which may be mitochondrial dysfunctions. Among them are: coronary heart disease (CHD), hypertension, cardiomyopathy, cerebrovascular accidents and type 2 diabetes mellitus (T2D). Very often, in the long course of the disease, complications may occur, leading to myocardial infarction or ischemic stroke and as a result, death. The main cause of mitochondrial dysfunction are point mitochondrial genome mutations. During the analysis of the literature, data showing the association of the mitochondrial genome mutations with the above diseases were revealed.