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6-ого Всемирного Конгресса «Митохондрия как мишень» (6th World Congress on Targeting Mitochondria, 28-30 October, 20 Ritz Carlton, Berlin, Germany, OREKHOV, N. Alexander ATHEROGENIC MITOCHONDRIAL MUTATIONS (Poster Presentation)); и Международного Саммита «Врожденный иммунитет»  (The 2015 Innate Immunity Summit, 17–19 November 2015, London, United Kingdom, Innate Immunity in Atherosclerosis, Professor Alexander N. Orekhov).

Abstract: «Innate immunity associated chronic reaction in arterial wall may trigger formation of atherosclerotic lesion. The main participants of innate immunity in atherosclerosis are multiple modified low density lipoprotein, hematogenous inflammatory cells as well as pluripotent resident cells of the arterial wall also involved in the immune response. Modifies lipoprotein particles form a self associates that arterial immune cells erroneously recognize as a foreign pathogen and trigger the innate immune response. If the mechanism of the innate immune system is working properly process terminates quickly. In case of breakdown of this mechanism reparative reaction may continue for a long time and transforms into chronic form. Chronic reaction is accompanied by local accumulation of lipids, increased proliferation of arterial cells, hypersecretion of extracellular matrix and violation of cell to cell communication that leads to the formation of atherosclerotic lesions».

 

«Ученые НИИ Атеросклероза приняли участие в важнейшем событии года – 26-м Международном Конгрессе по кардиологии в КНР (26th Great Wall International Congress of Cardiology - Asia Pacific Heart Congress and International Congress of Cardiovascular Prevention and Rehabilition), состоявшемся 29 октября-1 ноября текущего года. В частности, на Конгрессе были представлены 3 доклада по тематике проводимых институтом исследований (GW26-e0204 Variants of Mitochondrial Genome in Patients with Subclinical Atherosclerosis  doi:10.1016/j.jacc.2015.06.292; GW26-e0207 Monocyte activation in atherosclerosis  doi:10.1016/j.jacc.2015.06.1285; GW26-e0208 Naturally occurring multiple-modified low density lipoprotein(LDL); doi:10.1016/j.jacc.2015.06.1298), два из которых были номинированы как лучшие и награждены дипломами. Тексты докладов опубликованы в Journal of the American College of Cardiology, Volume 66, Issue 16, 2015».

Добавлена новая статья: Intimal pericytes as the second line of immune defence in atherosclerosis Ivanova EA, Bobryshev YV, Orekhov AN

Добавлена новая статья: Macrophage-mediated cholesterol handling in atherosclerosis. Chistiakov DA, Bobryshev YV, Orekhov AN

Добавлена новая статья: MAJOR MOLECULAR AND CELLULAR MANIFESTATIONS OF ATHEROSCLEROSIS Aladinsky VA, Nikiforov NG, Temchenko AV, Kotyashova SY, Gorlova OY, Azarova IN, Orekhov AN

Добавлена новая статья: Study of the activated macrophage transcriptome Novoselov VV, Sazonova MA, Ivanova EA, Orekhov AN.