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Новости

Добавлены новые статьи:

1 Links between atherosclerotic and periodontal disease.

 

Chistiakov DA, Orekhov AN, Bobryshev YV.

Exp Mol Pathol. 2016 Jan 14;100(1):220-235. doi: 10.1016/j.yexmp.2016.01.006.

 

2 Anti-cytokine therapy for prevention of atherosclerosis.

 

Kirichenko TV, Sobenin IA, Nikolic D, Rizzo M, Orekhov AN.

Phytomedicine. 2015 Dec 19. pii: S0944-7113(15)00370-0. doi: 10.1016/j.phymed.2015.12.002.

 

Добавлены новые статьи:

1 Cellular mechanisms of human atherosclerosis: Role of cell-to-cell communications in subendothelial cell functions.

Orekhov AN, Andreeva ER, Bobryshev YV.

Tissue Cell. 2015 Dec 14. pii: S0040-8166(15)30014-8. doi: 10.1016/j.tice.2015.11.002. [Epub ahead of print]

 

2 Cardiac Extracellular Vesicles in Normal and Infarcted Heart.

Chistiakov DA, Orekhov AN, Bobryshev YV.

Int J Mol Sci. 2016 Jan 5;17(1). pii: E63. doi: 10.3390/ijms17010063.

 

3 Anti-atherosclerotic effects of garlic preparation in freeze injury model of atherosclerosis in cholesterol-fed rabbits.

Sobenin IA, Andrianova IV, Lakunin KY, Karagodin VP, Bobryshev YV, Orekhov AN.

Phytomedicine. 2015 Nov 14. pii: S0944-7113(15)00334-7. doi: 10.1016/j.phymed.2015.10.014. [Epub ahead of print]

 

4 Editorial: Mechanistic Biomarkers: The Field for the Development of Non-Pharmaceutical and Pharmaceutical Approaches to Diagnostics, Prevention and Treatment of Chronic Diseases.

Sobenin IA, Orekhov AN.

Curr Pharm Des. 2016;22(3):265-7.

 

5 Editorial: The Crosstalk between Non-Pharmaceutical and Pharmaceutical Approaches to Prevention and Treatment of Chronic Diseases: Current Concepts and Perspectives.

Orekhov AN, Sobenin IA.

Curr Pharm Des. 2015;22(2):127-9.

 

Добавлена новая статья: Механизмы оттока холестерина из макрофагов — роль белка переноса фосфолипидов Карагодин В.П., Мухамедова М.Н., Орехов А.Н.

 

Добавлена новая статья: Endothelial Barrier and Its Abnormalities in Cardiovascular Disease. Chistiakov DA, Orekhov AN, Bobryshev YV.

 

Добавлена новая статья: Analysis of mitochondrial DNA heteroplasmic mutations A1555G, C3256T, T3336C, С5178А, G12315A, G13513A, G14459A, G14846А and G15059A in CHD patients with the history of myocardial infarction.

Mitrofanov KY, Zhelankin AV, Shiganova GM, Sazonova MA, Bobryshev YV, Postnov AY, Sobenin IA, Orekhov AN.

 

6-ого Всемирного Конгресса «Митохондрия как мишень» (6th World Congress on Targeting Mitochondria, 28-30 October, 20 Ritz Carlton, Berlin, Germany, OREKHOV, N. Alexander ATHEROGENIC MITOCHONDRIAL MUTATIONS (Poster Presentation)); и Международного Саммита «Врожденный иммунитет»  (The 2015 Innate Immunity Summit, 17–19 November 2015, London, United Kingdom, Innate Immunity in Atherosclerosis, Professor Alexander N. Orekhov).

Abstract: «Innate immunity associated chronic reaction in arterial wall may trigger formation of atherosclerotic lesion. The main participants of innate immunity in atherosclerosis are multiple modified low density lipoprotein, hematogenous inflammatory cells as well as pluripotent resident cells of the arterial wall also involved in the immune response. Modifies lipoprotein particles form a self associates that arterial immune cells erroneously recognize as a foreign pathogen and trigger the innate immune response. If the mechanism of the innate immune system is working properly process terminates quickly. In case of breakdown of this mechanism reparative reaction may continue for a long time and transforms into chronic form. Chronic reaction is accompanied by local accumulation of lipids, increased proliferation of arterial cells, hypersecretion of extracellular matrix and violation of cell to cell communication that leads to the formation of atherosclerotic lesions».